Current Issue : April - June Volume : 2019 Issue Number : 2 Articles : 5 Articles
The present study aimed at developing a new vesicular formulation capable of promoting\nthe protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and\ntheir efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer...............
Currently, one of the greatest health challenges worldwide is the resistance to antibiotic\ndrugs, which has led to the pursuit of new alternatives for the recovery of biological activity, where the\nuse of different types of nano-systems has shown an interesting potential. In this study, we evaluated\nthe antibiotic activity of a model drug (ampicillin) encapsulated within coated-nanoliposomes on\nstrains of Staphylococcus aureus with different antibiotic-resistance degrees. Hence, liposomes were\nelaborated by the ethanol injection method and were coated with a cationic polymer (Eudragit\nE-100) through the layer-by-layer process. Liposome characterization, such as size, polydispersity,\nzeta potential, and encapsulation efficiency were determined using dynamic light scattering and\nultrafiltration/centrifugation techniques. Although biological activity was evaluated using three\nATCC strains of S. aureus corresponding to ATCC 25923 (sensitive), ATCC 29213 (resistant) and ATCC\n43300 (very resistant). The results showed changes in size ..................
Atherosclerosis is no longer a disease attributed mainly to the high lipid content of the body but has come to be regarded as a chronic inflammatory disease with an autoimmune component. Atherosclerotic plaques occur preferentially in coronary arteries, where shear stress is oscillatory. Triton WR1339 and atherogenic diet causes decrease in shear stress leading to increased free radical production and endothelial dysfunctioning. It was hypothesized that esmolol increased blood velocity, decreased distal pressure and may cause reversal of abnormal endothelial shear stress, demonstrating a stronger cardioprotective effect, whereas etoricoxib inhibits the COX-2 enzymes thereby inhibits the generation of free radicals during PGs synthesis thus have atheroprotective property. The purpose of this study was to investigate the impact of etoricoxib and esmolol alone and the combination therapy of both. Rats were used for the experiment. All groups were given atherogenic diet and Triton WR-1339 for 60 days and for 7 days respectively. The blood serum was used to estimate the levels of TBARS, Catalase, total cholesterol, triglyceride, LDL and HDL using assay kits. It was concluded that treatment with etoricoxib (10 mg/kg), esmolol (10 mg/kg) and the combination of both drugs have atheroprotective, hypolipidemic, anti-inflammatory, antioxidant effects. This article in a completely novel way focuses on molecular mechanisms involved in the evolution of the atherosclerotic plaque and different novel targets that act at the starting stage of the plaque to the thrombus formation, this may pave the way for selecting optimal therapies and preventing plaque complications....
The development and application of novel nanospheres based on cationic and\nanionic random amphiphilic polypeptides with prolonged stability were proposed. The random\ncopolymers, e.g., poly(L-lysine-co-D-phenylalanine) (P(Lys-co-DPhe)) and poly(L-glutamic\nacid-co-D-phenylalanine) (P(Glu-co-DPhe)), with different amount of hydrophilic and hydrophobic\nmonomers were synthesized. The polypeptides obtained were able to self-assemble into nanospheres.\nSuch characteristics as size, PDI�����.....
This study examined the cardioprotective activity of human umbilical cord blood cells (hUCBC) in doxorubicin (Dxr) induced cardiomyopathy in Wistar rats. Wistar rats treated with doxorubicin (50 mg/kg i.p.) revealed cardiac damage that was manifested by the elevation of serum marker enzymes such as lactate dehydrogenase (LDH), aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT). The animals showed significant changes in the biochemical parameter such as in-vivo antioxidant enzyme levels (superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase) and lipid peroxidation levels, lipid profile and histopathological examination. Pretreatment with hUCBC significantly reversed elevation in serum marker enzymes and restored the enzyme activity and lipid peroxides to near normal levels. Restoration of cellular normality accredits the hUCBC with a cardioprotective role in Dxr-induced cardiac damage....
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